Near-normoglycemia and late diabetic complications

The first clinical description of diabetes mellitus originates from the Ebers papyrus written around 1550 B.C., while the turkish physician Aretaios of Capadokia (130-200 A.D.), who coined the term diabetes, is fabous for his precise description of the untreated disease: «Diabetes is an awkward affection melting down the flesh and limbs into the urine.... The patients ever stop making water.... Life is short and painful.... They are affected with nausea, restlessness and a burning thirst and at no distant term they exire.» The earliest mention of sweetness of diabetic urine dates back to the sixth century A.D. in the indian Vedic litterature. By this time complications of diabetes were described. In the Vedic litterature carbuncles are mentioned as a frequent complication and in the famous textbook by the persian physician Avicienna or Ibn Sina (980-1087 A.D.) gangrena in diabetics was described. Precise clinical,