Key result
In hypertensive adults, a higher triglyceride glucose index was significantly associated with a lower BMI-adjusted skeletal muscle mass index (adjusted β -5.27 for the highest versus lowest quartile).
Why the study?
The loss of muscle mass in people with hypertension is poorly understood, prompting an exploration of the relationship between TyG index and muscle mass.
Is a higher triglyceride glucose (TyG) index associated with a lower skeletal muscle mass index (SMI) in hypertensive adults?
Cross-Sectional (n=1,633)
Yes
Is a higher triglyceride glucose (TyG) index associated with a lower skeletal muscle mass index (SMI) in hypertensive adults?
Higher insulin resistance, as measured by the triglyceride glucose index, is independently associated with lower skeletal muscle mass in adults with hypertension.
TyG index negatively associates with muscle mass in hypertension; hypothesis-generating for sarcopenia risk, needs prospective confirmation.
BACKGROUND: The triglyceride glucose (TyG) index, an indicator of insulin resistance, is often associated with adverse outcomes in various cardiovascular diseases, while hypertension is associated with an increased risk of cardiovascular diseases. As the loss of muscle mass in people with hypertension is poorly understood, the current study aimed to explore the relationship between TyG index and muscle mass in hypertensive population. METHODS: We analyzed data from hypertensive adult participants in the National Health and Nutrition Examination Survey (NHANES) from 2011 to 2018. The TyG index and body mass index (BMI)-adjusted skeletal muscle mass index (SMI) were calculated and the relationship between the two was evaluated using multivariable linear regression and restricted cubic spline (RCS) regression models. RESULTS: A total of 1633 participants in the dataset were included for the final analysis. In the multivariable regression analysis, the adjusted β of SMI with a 95% confidence interval (CI) for the highest TyG index quartile was - 5.27 (- 9.79 to - 0.75), compared with the lowest quartile. A negative linear relationship between TyG index and SMI was plotted by RCS regression (nonlinear P = 0.128). Stratified models of non-smoking women of different ages also demonstrated that SMI decreased as TyG index increased (all P for trend < 0.05). CONCLUSION: This linear and negative correlation between TyG index and SMI in hypertensive patients suggests that insulin resistance adversely affects muscle mass.
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Zhu et al. (2023) conducted a cross-sectional in Hypertension (n=1,633). Triglyceride glucose (TyG) index vs. Lowest quartile of TyG index was evaluated on BMI-adjusted skeletal muscle mass index (SMI) (adjusted β -5.27, 95% CI -9.79 to -0.75, p=0.016 for trend). In hypertensive adults, a higher triglyceride glucose index was significantly associated with a lower BMI-adjusted skeletal muscle mass index (adjusted β -5.27 for the highest versus lowest quartile).
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