Three months of progressive pulmonary artery banding in dogs increased right atrial contractility (elastance 0.28 to 0.44 mm Hg/mL; P<0.04) to compensate for impaired right ventricular diastolic function.
Absolute Event Rate: 0.44% vs 0.28%
p-value: p=<0.04
BACKGROUND: Increased mortality in patients with chronic pulmonary hypertension has been associated with elevated right atrial (RA) pressure. However, little is known about the effects of chronic right ventricular (RV) pressure overload on RA and RV dynamics or the adaptive response of the right atrium to maintain RV filling. METHODS AND RESULTS: In 7 dogs, RA and RV pressure and volume (conductance catheter) were recorded at baseline and after 3 months of progressive pulmonary artery banding. RA and RV elastance (contractility) and diastolic stiffness were calculated, and RA reservoir and conduit function were quantified as RA inflow with the tricuspid valve closed versus open, respectively. With chronic pulmonary artery banding, systolic RV pressure increased from 34+/-7 to 70+/-17 mm Hg (P0.78). RV elastance and stiffness both increased (P<0.05), suggesting preserved systolic function but impaired diastolic function. In response, RA contractility improved (elastance increased from 0.28+/-0.12 to 0.44+/-0.13 mm Hg/mL; P<0.04), and the atrium became more distensible, as evidenced by increased reservoir function (49+/-14% versus 72+/-8%) and decreased conduit function (51+/-14% versus 28+/-8%; P<0.002). CONCLUSIONS: With chronic RV pressure overload, RV systolic function was preserved, but diastolic function was impaired. To compensate, RA contractility increased, and the atrium became more distensible to maintain filling of the stiffened ventricle. This compensatory response of the right atrium likely plays an important role in preventing clinical failure in chronic pulmonary hypertension.
Gaynor et al. (Tue,) conducted a other in chronic right ventricular pressure overload (n=7). progressive pulmonary artery banding vs. baseline was evaluated on Right atrial contractility (elastance, mm Hg/mL) (p=<0.04). Three months of progressive pulmonary artery banding in dogs increased right atrial contractility (elastance 0.28 to 0.44 mm Hg/mL; P<0.04) to compensate for impaired right ventricular diastolic function.