Key result
Three months of progressive pulmonary artery banding in dogs increased right atrial contractility (elastance 0.28 to 0.44 mm Hg/mL; P<0.04) to compensate for impaired right ventricular diastolic function.
Absolute Event Rate: 0.44% vs 0.28%
p-value: p=<0.04
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Animal data suggest right atrial compensation for RV diastolic impairment; leaves open relevance to human pulmonary hypertension.
Gaynor et al. (2005) studied chronic right ventricular pressure overload (n=7). progressive pulmonary artery banding vs. baseline was evaluated on Right atrial contractility (elastance, mm Hg/mL) (p=<0.04). Three months of progressive pulmonary artery banding in dogs increased right atrial contractility (elastance 0.28 to 0.44 mm Hg/mL; P<0.04) to compensate for impaired right ventricular diastolic function.
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