Electrophysiological and Biochemical Evidence That DEG/ENaC Cation Channels Are Composed of Nine Subunits

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Population

In vitro models expressing human epithelial Na+ channel subunits, FaNaCh, and BNC1

Design

Preclinical

Authors

Discussion

Does not alter clinical management of ENaC disorders; extends DEG/ENaC structural models for validation in native systems.

Population

In vitro models expressing human epithelial Na+ channel (hENaC) subunits (alpha, beta, gamma), FaNaCh, and BNC1

Intervention

Expression of wild-type and mutant subunits altering channel inhibition by methanethiosulfonates; sucrose gradient sedimentation

Outcome

Subunit stoichiometry of the DEG/ENaC complexessurrogate

This basic science study provides electrophysiological and biochemical evidence that DEG/ENaC cation channels are composed of nine subunits.

Snyder et al. (1998) studied this question.

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