Acidic residues in the second transmembrane domain (M2) of alpha-hENaC are critical components of the conductive pore, affecting ion permeation.
No takes yet. Share an insight, caveat, or question.
Remains preclinical with no therapeutic implications; leaves open targeted ENaC pore modulation in future models.
Langloh et al. (2000) studied this question.
Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context: