July 1, 2001AJP Cell Physiology

Point mutations in the post-M2 region of human α-ENaC regulate cation selectivity

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Structured PICO

Population

Xenopus oocytes expressing human alpha-epithelial Na+ channel (alpha-hENaC)

Intervention

Double point mutations of arginines in the post-M2 region of human alpha-ENaC (alphaR586E,R587E and alphaR589E,R591E)

Comparator

Wild-type human ENaC

Outcome

Macroscopic conductance, single-channel conductance, apparent equilibrium dissociation constant for Na+, maximum amiloride-sensitive Na+ current, and relative permeabilities of Li+ and K+ vs. Na+surrogate

The arginine-rich post-M2 region of human alpha-ENaC regulates cation selectivity and may form part of the channel pore.

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

No immediate clinical implications; leaves open the post-M2 region's role in ENaC selectivity for targeted research.

Cite This Study

Ji et al. (2001) studied this question.

synapsesocial.com/papers/6a83820a3a0d65749aa9b992 https://doi.org/10.1152/ajpcell.2001.281.1.c64

View Full Paper

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Point mutations in the post-M2 region of human α-ENaC regulate cation selectivity

Structured PICO

Discussion

Implication

Cite This Study

Point mutations in the post-M2 region of human α-ENaC regulate cation selectivity

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider