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January 1, 1980Intervirology

The Genome-Linked Protein of Picornaviruses

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Population

Poliovirus type 2 [32P]-RNA

Design

Preclinical

Authors

ABAlexander BabichHoward Hughes Medical InstituteEWEckard WimmerCalifornia Institute of TechnologyHTHaruka ToyodaKanazawa University

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Implication

Supports conserved 5' termini across poliovirus types; confirms linkage in animal models but leaves open human relevance.

Structured PICO

P
Population
Poliovirus type 2 [32P]-RNA
I
Intervention
Digestion with enzymes (proteinase K) and labeling with Bolton and Hunter reagent
O
Outcome
5'-terminal sequence of poliovirion type 2 RNAsurrogate

The study identifies the 5'-terminal sequence of poliovirus type 2 RNA and confirms its covalent linkage to the VPg protein.

Cite This Study

Babich et al. (1980) studied this question.

synapsesocial.com/papers/6a792fef8a3ae1c742320af3https://doi.org/10.1159/000149125
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The 5' end of poliovirus mRNA is not capped with m7G(5')ppp(5')Np.1976 · 277 citations
  2. 2Structural difference between the 5' termini of viral and cellular mRNA in poliovirus-infected cells: possible basis for the inhibition of host protein synthesis1976 · 120 citations
  3. 3The 5'-terminal structures of poliovirion RNA and poliovirus mRNA differ only in the genome-linked protein VPg.1977 · 182 citations
  4. 4Identification of a protein linked to nascent poliovirus RNA and to the polyuridylic acid of negative-strand RNA1978 · 113 citations
  5. 5The structure of poliovirus replicative form1980 · 35 citations