Key result
Antiphospholipid antibodies are linked to migraine in ~66% of referred neurological patients.
Observational (n=15)
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Observes frequent migraine and neurological deficits in patients with lupus anticoagulant, suggesting a potential clinical association between antiphospholipid antibodies and headache disorders.
The records of fifteen patients referred for neurological assessment and found to have lupus anticoagulant or elevated anticardiolipin antibodies were reviewed. The mean age for females in the group was 29.4 years and for males was 35. A diagnosis of migraine, either as an acute or chronic problem, was made in 10 (66%) of these patients. Seven of the 15 patients had ischemic stroke and two patients had other thrombotic complications associated with lupus anticoagulant. Three of the nine female patients with migraine had histories of spontaneous abortions. All migraine patients experienced transient or more prolonged neurological deficits with their headaches. An association between lupus anticoagulant and migraine can only be suggested. Data on the incidence of migraine in patients with lupus anticoagulant in the general medical population does not exist. Furthermore the prevalence of lupus anticoagulant in migraine sufferers is unknown. Therefore further studies are required to investigate this possible association.
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Hogan et al. (1988) conducted an observational in Lupus anticoagulant or elevated anticardiolipin antibodies (n=15). Lupus anticoagulant or elevated anticardiolipin antibodies was evaluated on Diagnosis of acute or chronic migraine. Lupus anticoagulant or elevated anticardiolipin antibodies were associated with a migraine diagnosis in 66% (10/15) and ischemic stroke in 47% (7/15) of referred neurological patients.
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