February 1, 1994BJOG An International Journal of Obstetrics & Gynaecology

The prevalence of lupus anticoagulant and anticardiolipin antibodies in women with a history of first trimester miscarriages

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Population

243 women with a history of two or more first trimester miscarriages attending a prepregnancy clinic and…

Design

Cohort

Authors

MMMarjory MacLeanNHS Ayrshire and Arran GCGrant CummingUniversity Hospitals Dorset NHS Foundation Trust FMFrances McCallGlasgow Royal Infirmary

Discussion

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Implication

May support targeted antiphospholipid testing in recurrent miscarriage; leaves open whether screening improves live-birth rates.

Structured PICO

Population

243 women with a history of two or more first trimester miscarriages (113 with two miscarriages, 130 with three or more miscarriages) attending a prepregnancy clinic and miscarriage antenatal clinic in a tertiary referral centre.

Outcome

Quantitative detection of lupus anticoagulant and anticardiolipin antibodies; number of miscarriages in women in the normal and the abnormal groupssurrogate

There is a significant prevalence (16.8%) of lupus anticoagulant and anticardiolipin antibodies in women with a history of recurrent first-trimester miscarriages, suggesting an association with early pregnancy loss.

Limitations

It is not known if these are the cause of miscarriage, markers for miscarriage, or if antiphospholipid antibodies develop as a result of a noncontinuing pregnancy.

Cite This Study

MacLean et al. (1994) studied this question.

synapsesocial.com/papers/6a8a55de41f4089922bd9206 https://doi.org/10.1111/j.1471-0528.1994.tb13073.x

View Full Paper

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The prevalence of lupus anticoagulant and anticardiolipin antibodies in women with a history of first trimester miscarriages

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

The prevalence of lupus anticoagulant and anticardiolipin antibodies in women with a history of first trimester miscarriages

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Also Consider

Also Consider