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January 1, 1985Journal of Obstetrics and Gynaecology

Fetal loss in systemic lupus: association with anticardiolipin antibodies

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Why the study?

Is there an association between maternal anticardiolipin antibodies and fetal loss in patients with systemic lupus erythematosus?

Population

23 patients with systemic lupus erythematosus who had had one or more spontaneous abortions or intra-uterine…

Comparison

Presence of maternal anticardiolipin antibodies vs Control group

Design

Case-control

Authors

GDGenevieve J. DerueHammersmith HospitalHEH. EnglertSt Vincent's Hospital SydneyEHE. Nigel HarrisHospital for Special Surgery

Discussion

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Implication

May inform risk stratification in SLE pregnancies; leaves open whether targeted therapy improves outcomes.

Structured PICO

Is there an association between maternal anticardiolipin antibodies and fetal loss in patients with systemic lupus erythematosus?

P
Population
23 patients with systemic lupus erythematosus who had had one or more spontaneous abortions or intra-uterine deaths
I
Intervention
Presence of maternal anticardiolipin antibodies (exposure)
C
Comparator
Control group
O
Outcome
Fetal loss (spontaneous abortions or intra-uterine deaths)hard clinical

Maternal anticardiolipin antibodies are associated with fetal loss in patients with systemic lupus erythematosus, suggesting potential therapeutic implications.

Cite This Study

Derue et al. (1985) studied this question.

synapsesocial.com/papers/6a72880ef44fa9f079dffa25https://doi.org/10.3109/01443618509067758
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Also Consider

Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Thrombosis, abortion, cerebral disease, and the lupus anticoagulant.1983 · 958 citations
  2. 2The Partial Thromboplastin Time with Kaolin: A Simple Screening Test for First Stage Plasma Clotting Factor Deficiencies1961 · 989 citations
  3. 3Thrombosis in Patients with the Lupus Anticoagulant1980 · 502 citations