Why the study?
Does the presence of untreated antiphospholipid antibodies increase the risk of miscarriage in women with a history of recurrent miscarriage compared to those with unexplained recurrent miscarriage?
Population
120 women with a history of recurrent miscarriage, including 20 with antiphospholipid antibodies who…
Comparison
No pharmacological treatment (observational) vs Cohort of 100 consecutive women with recurrent…
Design
Cohort
Follow-up
Through pregnancy
Authors
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Untreated APA associated with high miscarriage risk; hypothesis-generating for screening, with prospective trials needed before practice change.
Does the presence of untreated antiphospholipid antibodies increase the risk of miscarriage in women with a history of recurrent miscarriage compared to those with unexplained recurrent miscarriage?
Untreated pregnancies in women with recurrent miscarriage and antiphospholipid antibodies have a significantly higher rate of fetal loss (90%) compared to those with unexplained recurrent miscarriage.
Rai et al. (1995) studied this question.
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