Glucagon-like peptide-1: effect on pro-atrial natriuretic peptide in healthy males
Key result
A 2-hour native GLP1 infusion markedly increased urinary sodium excretion but did not significantly change proANP or proBNP concentrations in healthy young males.
Why the study?
Does a 2-h native GLP1 infusion increase plasma proANP concentrations in healthy young males?
Population
12 healthy young males
Comparison
2-h native GLP1 infusion vs Control (cross-over design)
Design
RCT, randomized, double-blinded
Follow-up
single-day
Authors
Discussion
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Overview
GLP-1 natriuresis occurs independently of ANP in healthy males; challenges ANP mediation hypothesis and extends mechanistic understanding in humans.
Key Points
- To determine whether native glucagon-like peptide-1 (GLP-1) stimulates atrial natriuretic peptide (ANP) release and mediates natriuretic responses in humans.
- Conducted a randomized, controlled, double-blind, single-day cross-over study in 12 healthy young males receiving a 2-hour native GLP-1 infusion.
- Quantified plasma mid-region proANP and N-terminal proBNP concentrations alongside urinary sodium excretion during and after infusion.
- GLP-1 infusion markedly increased urinary sodium excretion, which declined rapidly following infusion cessation.
- Plasma concentrations of proANP and proBNP exhibited no significant changes during GLP-1 administration.
Study Design
Type
RCT (n=12)
Blinding
Double-blind
Randomization
Randomized cross-over
Structured PICO
Does a 2-h native GLP1 infusion increase plasma proANP concentrations in healthy young males?
P
Population
12 healthy young males evaluated in a single-day cross-over study to assess the effects of a 2-hour GLP1 infusion.
I
Intervention
2-h native GLP1 infusion
C
Comparator
Control (cross-over design)
O
Outcome
Plasma proANP concentrationssurrogate
In healthy males, GLP1 infusion increases urinary sodium excretion without altering proANP or proBNP levels, suggesting the natriuretic effects of GLP1 are not mediated exclusively via ANP in humans.
Cite This Study
Skov et al. (2013) conducted an RCT in Healthy (n=12). Native GLP1 infusion vs. Control was evaluated on Plasma proANP and proBNP concentrations and urinary sodium excretion. A 2-hour native GLP1 infusion markedly increased urinary sodium excretion but did not significantly change proANP or proBNP concentrations in healthy young males.