Population
Influenza virus RNA (vRNA) promoter structure and viral polymerase
Comparison
Single and complementary double nucleotide… vs Wild-type vRNA promoter
Design
Preclinical
Authors
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May inform antiviral design targeting influenza promoter; confirms corkscrew model yet leaves open in vivo validation.
The study confirms the 'corkscrew' conformation of the influenza virus RNA promoter, identifying core structural elements required for viral polymerase recognition and ribonucleoprotein packaging.
Flick et al. (1999) studied this question.
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