Key result
In vitro assays demonstrated specific binding to the cRNA 5' terminus and suggested that a panhandle forms from the termini of the cRNA molecule, potentially playing a role in transcription.
Population
In vitro model using synthetic RNA corresponding to the 3' terminus of influenza A virus cRNA and…
Design
Preclinical
Authors
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Hypothesis-generating for panhandle-targeted influenza antivirals; leaves open functional confirmation in vivo.
The study provides evidence that a panhandle forms from the termini of the influenza A virus cRNA molecule, which may play a role in transcription to produce virion RNA.
Pritlove et al. (1995) studied Influenza A virus. In vitro transcription and polymerase binding assays was evaluated on Transcription and polymerase binding of influenza A virus cRNA termini. In vitro assays demonstrated specific binding to the cRNA 5' terminus and suggested that a panhandle forms from the termini of the cRNA molecule, potentially playing a role in transcription.
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