Muscle Involvement in Sarcoidosis

Allen Silverstein

doi:10.1001/archneur.1969.00480150025002

September 1, 1969Archives of Neurology

Muscle Involvement in Sarcoidosis

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Key Points

To review the clinical, histological, and electrophysiological characteristics of skeletal muscle involvement across different stages of systemic sarcoidosis.
Synthesized clinical observations, histological muscle biopsy findings, and electromyographic assessments in patients with systemic sarcoidosis.
Granulomas frequently occur histologically in skeletal muscle tissue without producing overt clinical signs such as weakness, wasting, tenderness, or myalgia.
Asymptomatic muscle involvement appears almost exclusively in early-stage sarcoidosis, whereas symptomatic myopathy and electromyographic abnormalities are rare and restricted to chronic disease.
Acute myalgia and muscle tenderness develop occasionally at any stage of disease, most commonly accompanying acute polyarthritis.

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Implication

Clinical review reveals frequent histological but largely asymptomatic skeletal muscle involvement in sarcoidosis, indicating symptomatic myopathy is confined to chronic stages.

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Cite This Study

Allen Silverstein (1969) studied this question.

synapsesocial.com/papers/6a7951b10b10e5535988f892 https://doi.org/10.1001/archneur.1969.00480150025002

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Muscle Involvement in Sarcoidosis

Key Points

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Implication

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Muscle Involvement in Sarcoidosis

Key Points

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Implication

Discussion

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