December 1, 1996Circulation

Mechanism of Action Potential Prolongation by RP 58866 and Its Active Enantiomer, Terikalant

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Population

Guinea pig ventricular myocytes, mouse AT-1 cells, and Xenopus oocytes expressing HERG

Design

Preclinical

Authors

NJNancy K. JurkiewiczUnited States Military Academy JWJixin WangChinese Academy of Medical Sciences & Peking Union Medical College BFBernard FerminiTexas Tech University

Discussion

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Implication

Questions IK1 selectivity assumptions in animal arrhythmia models; leaves open need for selective agents in future research.

Structured PICO

Population

Guinea pig ventricular myocytes, mouse AT-1 cells, and Xenopus oocytes expressing HERG

Intervention

RP 58866 and its active enantiomer, terikalant

Outcome

Effects on action potential (AP) and outward K+ currents (IKr and IK1)surrogate

RP 58866 and terikalant act primarily as potent blockers of IKr rather than specific blockers of IK1, challenging previous assumptions about their antiarrhythmic mechanism.

Cite This Study

Jurkiewicz et al. (1996) studied this question.

synapsesocial.com/papers/6a79583c7399945d38020ab7 https://doi.org/10.1161/01.cir.94.11.2938

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Mechanism of Action Potential Prolongation by RP 58866 and Its Active Enantiomer, Terikalant

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Mechanism of Action Potential Prolongation by RP 58866 and Its Active Enantiomer, Terikalant

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider