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November 5, 2016Journal of Genetic Engineering and BiotechnologyOpen Access

Common variants in TCF7L2 and CDKAL1 genes and risk of type 2 diabetes mellitus in Egyptians

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Why the study?

Do common variants in TCF7L2 and CDKAL1 genes increase the risk of type 2 diabetes mellitus in Egyptians?

Population

390 Egyptians, comprising 180 patients with type 2 diabetes mellitus (T2DM) and 210 control subjects.

Comparison

Presence of TCF7L2 and CDKAL1 single nucleotide… vs Wild genotype carriers / control subjects

Design

Case-control

Authors

DEDalia El-LebedyMisr University for Science and TechnologyIAIngy AshmawyResearch Institute of Ophthalmology

Discussion

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Member takes

Overview

Provides Egyptian-specific data; leaves open replication and clinical utility in diverse populations.

Structured PICO

Do common variants in TCF7L2 and CDKAL1 genes increase the risk of type 2 diabetes mellitus in Egyptians?

P
Population
390 Egyptians, comprising 180 patients with type 2 diabetes mellitus (T2DM) and 210 control subjects.
I
Intervention
Presence of TCF7L2 (rs7903146 and rs12255372) and CDKAL1 (rs7756992) single nucleotide polymorphisms
C
Comparator
Wild genotype carriers / control subjects
O
Outcome
Risk of type 2 diabetes mellitus (T2DM)

Common variants in the TCF7L2 gene, specifically rs12255372 and rs7903146, are significantly associated with an increased risk of type 2 diabetes mellitus in the Egyptian population.

Cite This Study

El-Lebedy et al. (2016) studied this question.

synapsesocial.com/papers/6a79589cb2ad017e403208bdhttps://doi.org/10.1016/j.jgeb.2016.10.004
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Association of gene variants with susceptibility to type 2 diabetes among Omanis2015 · 44 citations
  2. 2Diagnosis and Classification of Diabetes Mellitus2010 · 14,027 citations
  3. 3TCF-4 Mediates Cell Type-specific Regulation of Proglucagon Gene Expression by β-Catenin and Glycogen Synthase Kinase-3β2004 · 414 citations
  4. 4CDKAL1 and type 2 diabetes: a global meta-analysis2010 · 83 citations
  5. 5Association between TCF7L2gene polymorphisms and susceptibility to Type 2 Diabetes Mellitus: a large Human Genome Epidemiology (HuGE) review and meta-analysis2009 · 266 citations