Population
Cat sympathetic preganglionic neurons of the intermediolateral nucleus in spinal cord slices
Comparison
Superfusion with noradrenaline (NA) 10-50 microM vs Normal Krebs solution (control conditions)
Design
Preclinical
Authors
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No immediate clinical implications; leaves open noradrenergic modulation of human sympathetic excitability pending mammalian validation.
Noradrenaline induces an afterdepolarization in cat sympathetic preganglionic neurons via a mechanism likely involving a Ca-activated Na conductance, potentially modulating responsiveness to excitatory inputs.
Yoshimura et al. (1987) studied this question.