Key result
Hypertension linked to increased sodium and water concentrations in renal arteries and psoas muscle.
Why the study?
The relationship between increased sodium and water content in arteries and arterioles and the mechanism of increased peripheral resistance in hypertension was investigated.
Population
Human hypertensive subjects and hypertensive rats
Comparison
Hypertensive subjects and rats vs normal sodium and water content
Design
Observational study
Authors
Loading...
Arterial sodium-water accumulation may increase peripheral resistance; leaves open causality and clinical relevance in humans.
Observational
Increased sodium and water content in arterial walls may contribute to increased peripheral resistance in hypertension, providing a mechanistic rationale for the efficacy of low-sodium diets.
Tobian et al. (1952) conducted an observational in Arterial Hypertension. Hypertension vs. Normotensive subjects was evaluated on Sodium and water concentration in renal artery and psoas muscle. Hypertension was associated with increased sodium and water concentrations in the renal artery and psoas muscle of human subjects and the aortas of rats.