Why the study?
Do serial measurements of NT-pro BNP and CT-ANP correlate with cardiac remodeling in a canine model of aortic stenosis?
Population
6 male Beagles with a model of compensated aortic stenosis
Comparison
Aortic constriction with a polyester band vs Baseline (before surgery)
Design
Preclinical
Follow-up
6 months
Authors
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Should not guide human aortic stenosis care; leaves open NT-proBNP translation from canine pressure-overload models.
Do serial measurements of NT-pro BNP and CT-ANP correlate with cardiac remodeling in a canine model of aortic stenosis?
NT-pro BNP, but not CT-ANP, correlates with left ventricular end-diastolic pressure and septal thickness in a canine model of pressure overload, suggesting its utility in stratifying early-stage ventricular remodeling.
Hori et al. (2008) studied this question.
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