Why the study?
Does cyclopiazonic acid alter the frequency-dependence of the contraction-relaxation cycle in guinea-pig isolated atrium?
Population
Guinea-pig isolated left atrium and isolated sarcoplasmic reticulum (SR) membranes
Comparison
Cyclopiazonic acid (CPA) (0.3-100 microM) vs Absence of CPA (baseline frequency-dependence)
Design
Preclinical
Authors
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Implicates SR Ca2+-ATPase in frequency-dependent atrial contractility; leaves open relevance to human heart failure.
Does cyclopiazonic acid alter the frequency-dependence of the contraction-relaxation cycle in guinea-pig isolated atrium?
Cyclopiazonic acid selectively inhibits cardiac SR Ca2+-ATPase, demonstrating that functional SR Ca2+-ATPase is necessary for the normal contraction-relaxation cycle and its frequency-dependence in guinea-pig cardiac tissue, which may relate to mechanisms of heart failure.
Yard et al. (1994) studied this question.
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