Population
Isolated urinary bladder myocytes from guinea pigs
Comparison
Cyclopiazonic acid (CPA) vs Control conditions (baseline)
Design
Preclinical
Authors
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SERCA inhibition data support SR Ca2+ buffering in bladder myocytes; hypothesis-generating and leaves open translation to human cardiovascular physiology.
Inhibition of SERCA by CPA in guinea pig urinary bladder myocytes suggests that Ca2+ sequestration by the sarcoplasmic reticulum buffers part of the Ca2+ influx during slow depolarizations.
Yoshikawa et al. (1996) studied this question.
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