February 7, 2005HypertensionOpen Access

Superoxide Mediates Angiotensin II–Induced Influx of Extracellular Calcium in Neural Cells

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Population

Mouse neuroblastoma Neuro-2A cells

Comparison

Angiotensin II stimulation with… vs Angiotensin II stimulation alone, Ca2+-free…

Design

Preclinical

Authors

MZMatthew C. ZimmermanUniversity of North Carolina at Chapel Hill RSRam V. SharmaInstitute of Management Technology RDRobin L. DavissonGeneral Cardiology

Discussion

Member takes

Implication

Does not inform clinical practice; hypothesis-generating for superoxide in Ang II neural calcium signaling and central BP control.

Structured PICO

Population

Mouse neuroblastoma Neuro-2A cells

Intervention

Angiotensin II stimulation with adenoviral-mediated overexpression of cytoplasm-targeted O2*- dismutase (AdCuZnSOD) or dominant-negative Rac1 (AdN17Rac1)

Comparator

Angiotensin II stimulation alone, Ca2+-free medium, or pretreatment with CdCl2

Outcome

Intracellular Ca2+ concentration ([Ca2+]i)surrogate

Superoxide mediates Angiotensin II-induced influx of extracellular calcium in neural cells, highlighting a potential intracellular signaling mechanism for central neural control of blood pressure.

Cite This Study

Zimmerman et al. (2005) studied this question.

synapsesocial.com/papers/6a796fafdd2e05b79c3207a4 https://doi.org/10.1161/01.hyp.0000153463.22621.5e

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Superoxide Mediates Angiotensin II–Induced Influx of Extracellular Calcium in Neural Cells

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Superoxide Mediates Angiotensin II–Induced Influx of Extracellular Calcium in Neural Cells

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider