Why the study?
Does NAD(P)H oxidase inhibition attenuate the neuronal chronotropic actions of Angiotensin II in primary cultured neurons?
Does NAD(P)H oxidase inhibition attenuate the neuronal chronotropic actions of Angiotensin II in primary cultured neurons?
Angiotensin II regulates neuronal activity via ROS generation and inhibition of delayed rectifier potassium current, a critical cellular event in central cardiovascular regulation.
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ROS inhibition attenuates Ang II neuronal effects in vitro; leaves open translation to central cardiovascular regulation or hypertension therapies.
Sun et al. (2005) studied this question.
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