January 27, 2006Arteriosclerosis Thrombosis and Vascular BiologyOpen Access

Angiotensin II Attenuates Endothelium-Dependent Responses in the Cerebral Microcirculation Through Nox-2–Derived Radicals

View Full Paper

Ask AI

Bookmark

Why the study?

Does Angiotensin II impair endothelium-dependent responses in the cerebral microcirculation through Nox-2-derived radicals in mice?

Structured PICO

Does Angiotensin II impair endothelium-dependent responses in the cerebral microcirculation through Nox-2-derived radicals in mice?

Population

Anesthetized mice equipped with a cranial window (including wild-type and nox-2 knockout mice)

Intervention

Angiotensin II (0.25+/-0.02 microg/kg per minute for 30 to 45 minutes)

Comparator

Control conditions, co-administration with losartan, ROS scavenger Mn(III) tetrakis (4-benzoic acid) porphyrin chloride, NADPH oxidase peptide inhibitor gp91ds-tat, or nox-2 knockout mice

Outcome

Cerebral blood flow (CBF) increase produced by endothelium-dependent vasodilators (acetylcholine, bradykinin, and A23187) and cerebrovascular ROS productionsurrogate

Angiotensin II impairs endothelial regulation of the cerebral microcirculation through AT1 receptor-mediated oxidative stress generated by a nox-2-containing NADPH oxidase.

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

Implicates Nox-2 in Ang II-mediated cerebral endothelial dysfunction in mice; leaves open relevance to human cerebrovascular disease.

Cite This Study

Girouard et al. (2006) studied this question.

synapsesocial.com/papers/6a8fc4713fc7ffb22a40c19b https://doi.org/10.1161/01.atv.0000205849.22807.6e

Topics

Hypertension management

View Full Paper

Ask AI

Bookmark

Angiotensin II Attenuates Endothelium-Dependent Responses in the Cerebral Microcirculation Through Nox-2–Derived Radicals

Structured PICO

Discussion

Implication

Cite This Study

Topics

Angiotensin II Attenuates Endothelium-Dependent Responses in the Cerebral Microcirculation Through Nox-2–Derived Radicals

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Topics

Also Consider