What question did this study set out to answer?

To describe the rationale and structure of a specialized multidisciplinary amiodarone clinic and evaluate its impact on guideline adherence and adverse effect detection.

November 12, 1998Pharmacotherapy The Journal of Human Pharmacology and Drug TherapyOpen Access

Rationale, Development, and Clinical Outcomes of a Multidisciplinary Amiodarone Clinic

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Why the study?

Does a multidisciplinary amiodarone clinic improve adherence to monitoring guidelines and detection of adverse events in patients receiving amiodarone?

Population

60 patients receiving amiodarone referred by their primary physicians

Comparison

Management in a specialized, multidisciplinary… vs Pre-referral care (historical control)

Design

Cohort

Follow-up

Mean 9.2+/-5.5 months after referral

Authors

CSCynthia A. SanoskiThomas Jefferson University MSMarieke Dekker SchoenIllinois College RGRose C. GonzalezUniversity of Illinois Chicago

Discussion

Member takes

Implication

Clinic enrollment was associated with better monitoring and adverse event detection; hypothesis-generating for multidisciplinary models and requires prospective validation.

Key Points

To describe the rationale and structure of a specialized multidisciplinary amiodarone clinic and evaluate its impact on guideline adherence and adverse effect detection.
Monitored N=60 patients referred to a multidisciplinary ambulatory clinic for amiodarone therapy, with follow-up tracking before (16.3±25.5 months) and after (9.2±5.5 months) enrollment.
Implemented standardized protocol tracking baseline history alongside semiannual liver and thyroid function tests, chest radiographs, and annual pulmonary function tests.
Guideline-recommended laboratory monitoring increased from 23% (14/60) of patients prior to referral to 90% (54/60) after clinic enrollment (p<0.001).
Unrecognized adverse events were identified in 35% (21/60) of patients, prompting amiodarone discontinuation in 6 patients and dosage adjustments in 48.4% (29/60).

Structured PICO

Does a multidisciplinary amiodarone clinic improve adherence to monitoring guidelines and detection of adverse events in patients receiving amiodarone?

Population

60 patients receiving amiodarone referred by their primary physicians

Intervention

Management in a specialized, multidisciplinary amiodarone clinic with standardized monitoring (liver function tests, thyroid function tests, and chest radiographs every 6 months; pulmonary function tests annually)

Comparator

Pre-referral care (historical control)

Outcome

Adherence to guideline-recommended laboratory testingsafety

Implementation of a multidisciplinary amiodarone clinic significantly improves adherence to monitoring guidelines and enhances the early detection of drug-related toxicities.

Cite This Study

Sanoski et al. (1998) studied this question.

synapsesocial.com/papers/6a79704314b028facf0dc5db https://doi.org/10.1002/j.1875-9114.1998.tb03951.x

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Implication

Clinic enrollment was associated with better monitoring and adverse event detection; hypothesis-generating for multidisciplinary models and requires prospective validation.

Rationale, Development, and Clinical Outcomes of a Multidisciplinary Amiodarone Clinic

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Rationale, Development, and Clinical Outcomes of a Multidisciplinary Amiodarone Clinic

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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Also Consider