Population
Spontaneously diabetic Goto-Kakizaki rats (model of type 2 DM) and non-diabetic Wistar controls
Comparison
Experimental myocardial infarction induced by… vs Sham operation and non-diabetic Wistar controls
Design
Preclinical
Follow-up
12 weeks
Authors
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Hypothesis-generating for diabetic post-MI remodeling pathways; leaves open clinical translation.
In a rat model of type 2 diabetes, post-infarct heart failure is associated with exacerbated cardiac remodeling mediated by alterations in the Akt-FOXO3a, Sirt1-p53, and p38 MAPK pathways.
Vahtola et al. (2010) studied this question.
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