Why the study?
Do antioxidants (tempol or vitamin E) prevent Angiotensin II-induced increases in blood pressure and endothelin in Sprague-Dawley rats?
Do antioxidants (tempol or vitamin E) prevent Angiotensin II-induced increases in blood pressure and endothelin in Sprague-Dawley rats?
Antioxidants prevent Angiotensin II-induced hypertension by reducing oxidant stress and endothelin levels in a rat model.
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Does not inform clinical practice; leaves open whether antioxidants blunt Ang II hypertension in humans.
Ortíz et al. (2001) studied this question.
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