Why the study?
What causes sudden collapse and death during quinidine administration, and what are possible remedies?
What causes sudden collapse and death during quinidine administration, and what are possible remedies?
This investigation aims to elucidate the mechanisms behind sudden collapse and death associated with quinidine administration and to suggest potential remedies.
Alerts to quinidine collapse risk; leaves open mechanistic elucidation and remedies for safer use.
Sudden collapse, sometimes followed by death, still occurs during the administration of quinidine, in spite of selection of cases by criteria that are now widely accepted. Post-mortem examinations show in some cases an embolism in some vital organ, but in others no obvious cause of death can be found. The object of this investigation was to throw some light on the cause of death in these patients and to suggest possible remedies.
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Finnegan et al. (1954) studied this question.
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