Key result
Quinidine sulphate 0.2 g t.i.d. did not reduce the occurrence of arrhythmias other than extrasystoles in acute myocardial infarction, with no difference in sudden deaths compared to no treatment.
Why the study?
Does quinidine sulphate 0.2 g t.i.d. prevent arrhythmias in patients with acute myocardial infarction?
RCT
Does quinidine sulphate 0.2 g t.i.d. prevent arrhythmias in patients with acute myocardial infarction?
Prophylactic quinidine sulphate in acute myocardial infarction does not reduce major arrhythmias and may increase the risk of dangerous complications.
Prophylactic quinidine should not be used in acute MI; leaves open whether any antiarrhythmic reduces sudden death.
A controlled study has been carried out to examine the possible prophylactic antiarrhythmic effect of quinidine sulphate 0.2 g t.i.d. in acute myocardial infarction. No difference was found in the occurrence of the various types of arrhythmias, apart from extrasystoles, which were significantly less frequent in the treated than in the non‐treated group. An analysis of the causes of death revealed no difference in sudden and unexpected deaths between the two groups. There was rather a vague impression that quinidine might have contributed to dangerous complications and death in a few patients. The possible reasons for these findings are discussed in relation to the observations from the literature.
No takes yet. Share an insight, caveat, or question.
Anderssen et al. (1968) conducted an RCT in acute myocardial infarction. quinidine sulphate vs. non-treated group was evaluated on occurrence of various types of arrhythmias. Quinidine sulphate 0.2 g t.i.d. did not reduce the occurrence of arrhythmias other than extrasystoles in acute myocardial infarction, with no difference in sudden deaths compared to no treatment.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: