Why the study?
Does routine use of quinidine reduce the incidence of arrhythmias and sudden unexpected death in patients with acute myocardial infarction?
Does routine use of quinidine reduce the incidence of arrhythmias and sudden unexpected death in patients with acute myocardial infarction?
Quinidine's routine use in acute MI for arrhythmia or sudden-death prevention remains unproven; leaves open need for randomized trials before any practice change.
DURING the course of a study on the use of Dicumarol in acute myocardial infarction, the value of the routine use of quinidine in this condition was also investigated. In particular, the investigation was directed toward ascertaining whether or not the incidence of arrhythmias and sudden unexpected death could be altered. The first 55 patients in the Dicumarol study had received no quinidine and were therefore designated as a control group. The remaining 66 patients received 0.2 gm. of quinidine sulfate by mouth four times a day, at 8 a.m., 12 noon, 4 p.m. and 8 p.m. This dosage schedule . . .
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Cutts et al. (1952) studied this question.
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