Key result
SLE non-T lymphocytes fail to stimulate normal autologous T-cell proliferation.
Observational
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Shows non-T cells fail to stimulate autologous T-cell proliferation in systemic lupus erythematosus, suggesting a mechanism for defective suppressor activity and autoantibody production.
The autologous mixed lymphocyte reaction is impaired in patients with systemic lupus erythematosus. This is because nonthymus-derived (T)-lymphocyte preparations from such patients do not stimulate autologous T-lymphocyte proliferation normally. This defect may explain the impaired generation of suppressor activity in systemic lupus erythematosus and thereby the occurrence of autoantibodies in this disease.
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Kuntz et al. (1979) conducted an observational in Systemic lupus erythematosus. Nonthymus-derived (T)-lymphocyte preparations was evaluated on Autologous T-lymphocyte proliferation in the autologous mixed lymphocyte reaction. Nonthymus-derived lymphocyte preparations from systemic lupus erythematosus patients fail to stimulate normal autologous T-lymphocyte proliferation.
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