February 1, 1994Circulation
Native beta-adrenergic support for left ventricular dysfunction in experimental mitral regurgitation normalizes indexes of pump and contractile function.
Why the study?
Does acute beta-blockade reveal innate myocardial depression in a canine model of chronic mitral regurgitation?
Population
Canine model of experimental mitral regurgitation producing left ventricular dysfunction after 3 months of…
Comparison
Acute beta-blockade vs Unblocked state
Design
Preclinical
Follow-up
3 months
Authors
Discussion
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Implication
Endogenous adrenergic support may mask contractile depression in chronic MR; hypothesis-generating and should not guide clinical decisions.
Structured PICO
Does acute beta-blockade reveal innate myocardial depression in a canine model of chronic mitral regurgitation?
P
Population
Canine model of experimental mitral regurgitation producing left ventricular dysfunction after 3 months of volume overload
I
Intervention
Acute beta-blockade
C
Comparator
Unblocked state (baseline and after 3 months of chronic mitral regurgitation)
O
Outcome
Indexes of pump and contractile function (mass-corrected slope of the end-ejection stress-volume relation [EESVR], end-systolic stiffness constant, ejection fraction-end-systolic stress, and mean velocity of circumferential fiber shortening [VCF]-end-systolic stress relations)surrogate
In an experimental model of chronic mitral regurgitation, significant innate myocardial contractile depression is masked by endogenous adrenergic support and only revealed after acute beta-blockade.
Cite This Study
Nagatsu et al. (1994) studied this question.