Key result
Beta-blockade alone improved end-systolic stiffness to 3.5±0.4, whereas preventing bradycardia with pacing during beta-blockade failed to improve stiffness (2.9±0.2) in dogs with LV dysfunction.
Why the study?
Does beta-blockade-induced bradycardia improve left ventricular dysfunction in a canine model of mitral regurgitation?
Population
Dogs with mitral regurgitation and left ventricular dysfunction
Comparison
Beta-blockers alone (group betaB) for 3 months vs Beta-blockers plus pacing to prevent bradycardia…
Design
Preclinical
Follow-up
3 months
Authors
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Bradycardia may mediate beta-blocker effects on LV stiffness in canine MR; leaves open human translation.
Does beta-blockade-induced bradycardia improve left ventricular dysfunction in a canine model of mitral regurgitation?
Absolute Event Rate: 3.5% vs 2.9%
Nagatsu et al. (2000) studied mitral regurgitation and LV dysfunction. beta-blockers vs. beta-blockers and pacing was evaluated on end-systolic stiffness constant. Beta-blockade alone improved end-systolic stiffness to 3.5±0.4, whereas preventing bradycardia with pacing during beta-blockade failed to improve stiffness (2.9±0.2) in dogs with LV dysfunction.
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