August 17, 1999CirculationOpen Access

Effects of β-Adrenergic Blocking Therapy on Left Ventricular Diastolic Relaxation Properties in Patients With Dilated Cardiomyopathy

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Why the study?

Does metoprolol improve left ventricular diastolic relaxation properties in patients with dilated cardiomyopathy?

Population

18 patients with dilated cardiomyopathy in normal sinus rhythm, no arteriographic evidence of coronary…

Comparison

Metoprolol therapy for 6 months vs No metoprolol therapy

Design

Cohort

Follow-up

6 months

Authors

WDWilliam DevlinOakland University SDSunil K. DasLa Jolla Institute for Immunology JPJanet A. PetrushaUnited States Department of Veterans Affairs

Discussion

Member takes

Implication

Metoprolol was associated with improved LV diastolic properties in dilated cardiomyopathy; leaves open need for randomized confirmation of clinical benefit.

Structured PICO

Does metoprolol improve left ventricular diastolic relaxation properties in patients with dilated cardiomyopathy?

Population

18 patients with dilated cardiomyopathy in normal sinus rhythm, no arteriographic evidence of coronary artery disease, and LVEF ≤40%

Intervention

Metoprolol therapy for 6 months

Comparator

No metoprolol therapy (4 comparable patients serving as controls)

Outcome

Left ventricular end-diastolic pressure and diastolic relaxation properties (isovolumic relaxation index, LV chamber stiffness constant, LV volume elastance, myocardial stiffness constant)surrogate

Metoprolol therapy improves left ventricular diastolic properties and reduces end-diastolic pressure in patients with dilated cardiomyopathy through more complete myocardial relaxation.

Cite This Study

Devlin et al. (1999) studied this question.

synapsesocial.com/papers/6a7e2940884bedf30483dfbd https://doi.org/10.1161/01.cir.100.7.729

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Implication

Metoprolol was associated with improved LV diastolic properties in dilated cardiomyopathy; leaves open need for randomized confirmation of clinical benefit.

Effects of β-Adrenergic Blocking Therapy on Left Ventricular Diastolic Relaxation Properties in Patients With Dilated Cardiomyopathy

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Effects of β-Adrenergic Blocking Therapy on Left Ventricular Diastolic Relaxation Properties in Patients With Dilated Cardiomyopathy

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider