Key result
Metoprolol significantly increased E-wave deceleration time compared to placebo (152 to 216 ms vs 185 to 181 ms; P=0.01) in patients with idiopathic dilated cardiomyopathy.
Why the study?
Does metoprolol improve diastolic function in patients with idiopathic dilated cardiomyopathy?
Population
77 patients with idiopathic dilated cardiomyopathy
Comparison
Metoprolol for 12 months vs Placebo for 12 months
Design
RCT, randomly assigned
Follow-up
12 months
Authors
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Supports metoprolol for diastolic improvement in idiopathic dilated cardiomyopathy; extends beta-blocker evidence to filling patterns that may precede systolic recovery.
RCT (n=77)
Randomized
Yes
Does metoprolol improve diastolic function in patients with idiopathic dilated cardiomyopathy?
p-value: p=0.01
Long-term metoprolol therapy in idiopathic dilated cardiomyopathy significantly improves diastolic filling patterns, which may precede and account for subsequent systolic recovery.
Andersson et al. (1996) conducted an RCT in Idiopathic dilated cardiomyopathy (n=77). Metoprolol vs. Placebo was evaluated on Change in E-wave deceleration time (p=0.01). Metoprolol significantly increased E-wave deceleration time compared to placebo (152 to 216 ms vs 185 to 181 ms; P=0.01) in patients with idiopathic dilated cardiomyopathy.
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