Why the study?
Does acute intravenous metoprolol alter diastolic function, heart rate, and myocardial metabolism in patients with heart failure?
Population
57 patients with heart failure
Comparison
Metoprolol 13 +/- 3.1 mg intravenously vs Baseline (pre-injection)
Design
Cohort
Follow-up
acute
Authors
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Acute IV metoprolol was associated with lower myocardial O2 consumption in HF; hypothesis-generating for beta-blocker benefits, needs randomized confirmation.
Does acute intravenous metoprolol alter diastolic function, heart rate, and myocardial metabolism in patients with heart failure?
Acute intravenous metoprolol in severe heart failure reduces myocardial metabolic demand and prolongs the diastolic filling phase, providing a physiological rationale for the long-term benefits of beta-blockade.
Andersson et al. (1993) studied this question.
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