Why the study?
Does metoprolol improve myocardial function independent of heart rate reduction in patients with heart failure?
Population
48 patients with congestive heart failure
Comparison
Metoprolol vs Placebo
Design
Cohort, Placebo-controlled for 30 patients
Follow-up
3, 6, and 12 months
Authors
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Supports metoprolol-associated myocardial recovery independent of heart rate in HF; hypothesis-generating and requires randomized confirmation.
Does metoprolol improve myocardial function independent of heart rate reduction in patients with heart failure?
Long-term metoprolol treatment improves the intrinsic force-frequency relationship of myocardial performance in heart failure, demonstrating that a lower heart rate is not strictly necessary to maintain cardiac function once myocardial recovery has occurred.
Bert Andersson (1999) studied this question.
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