Why the study?
Does a single preoperative dose of metronidazole alone or with cefuroxime reduce postoperative infectious complications in children operated upon for uncomplicated appendicitis compared to no antibiotics?
Population
544 children operated upon for uncomplicated appendicitis
Comparison
Single preoperative dose of metronidazole alone… vs No antibiotics
Design
RCT, Randomised into three groups
Authors
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Supports single-dose metronidazole prophylaxis in pediatric gangrenous appendicitis; confirms anaerobic coverage benefit in this RCT.
Does a single preoperative dose of metronidazole alone or with cefuroxime reduce postoperative infectious complications in children operated upon for uncomplicated appendicitis compared to no antibiotics?
A single preoperative dose of metronidazole significantly decreases the rate of postoperative infectious complications in children with gangrenous appendicitis, with no added benefit from cefuroxime.
Söderquist-Elinder et al. (1995) studied this question.
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