November 20, 2013Nucleic Acids ResearchOpen Access

Adaptation of theHaloarcula hispanicaCRISPR-Cas system to a purified virus strictly requires a priming process

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Population

Haloarcula hispanica infected by newly isolated virus HHPV-2

Design

Preclinical

Authors

MLMing LiChinese Academy of Sciences RWRui WangXinyang College of Agriculture and Forestry DZDahe ZhaoChinese Academy of Sciences

Discussion

Member takes

Implication

Highlights priming-dependent CRISPR specificity in archaea; leaves open conservation and applications across systems.

Structured PICO

Population

Haloarcula hispanica infected by newly isolated virus HHPV-2

Intervention

Type I-B CRISPR system adaptation process

Outcome

Spacer acquisition from viral sequences

The study demonstrates that efficient adaptation of the Haloarcula hispanica CRISPR-Cas system to a purified virus strictly requires a priming process, providing insights into the discrimination mechanism at the adaptation level.

Cite This Study

Li et al. (2013) studied this question.

synapsesocial.com/papers/6a7978fc0b10e55359890b07 https://doi.org/10.1093/nar/gkt1154

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Adaptation of theHaloarcula hispanicaCRISPR-Cas system to a purified virus strictly requires a priming process

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Adaptation of theHaloarcula hispanicaCRISPR-Cas system to a purified virus strictly requires a priming process

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider