What question did this study set out to answer?

To assess body fluid compartments, kidney function, and neurohormonal activation in patients with severe chronic heart failure receiving diuretic therapy judged adequate by clinical assessment.

May 1, 1989European Heart Journal

Treatment of heart failure with diuretics: body compartments, renal function and plasma hormones

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Why the study?

Does clinical assessment reliably indicate the restoration of normal body fluid volumes with diuretics in patients with severe chronic heart failure?

Population

13 patients with severe chronic heart failure

Design

Cross-sectional

Authors

IAI.S. ANANADPost Graduate Institute of Medical Education and Research NVN. VeallMRC Clinical Trials Unit at UCL DKD. KalraColumbia University

Discussion

Member takes

Implication

Clinical assessment may reliably indicate euvolemia in severe HF on diuretics; leaves open whether persistent neurohormonal activation warrants additional targets.

Key Points

To assess body fluid compartments, kidney function, and neurohormonal activation in patients with severe chronic heart failure receiving diuretic therapy judged adequate by clinical assessment.
Evaluated 13 patients with severe chronic heart failure deemed appropriately treated with diuretics by their referring physicians (N=13).
Measured body fluid compartments, parameters of renal function, and circulating plasma hormones, including noradrenaline, aldosterone, and renin activity.
Body fluid compartments were restored to within the normal physiological range following diuretic therapy.
Renal function remained substantially impaired, accompanied by elevated levels of plasma noradrenaline, aldosterone, and renin activity despite normalized fluid volumes.

Structured PICO

Does clinical assessment reliably indicate the restoration of normal body fluid volumes with diuretics in patients with severe chronic heart failure?

Population

13 patients with severe chronic heart failure

Intervention

Diuretic therapy guided by clinical assessment

Outcome

Body fluid compartments, renal function, and plasma hormonessurrogate

Careful clinical assessment by an experienced physician is a reliable method for assessing the restoration of normal body fluid volumes with diuretics in severe chronic heart failure.

Cite This Study

ANANAD et al. (1989) studied this question.

synapsesocial.com/papers/6a797a14fbd9051d3b0dc8fe https://doi.org/10.1093/oxfordjournals.eurheartj.a059508

Topics

Heart failure HFrEF treatment Heart failure hospitalization

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Implication

Clinical assessment may reliably indicate euvolemia in severe HF on diuretics; leaves open whether persistent neurohormonal activation warrants additional targets.

Treatment of heart failure with diuretics: body compartments, renal function and plasma hormones

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Topics

Treatment of heart failure with diuretics: body compartments, renal function and plasma hormones

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider