Why the study?
Does N-acetylcysteine prevent the deleterious effects of TNF-alpha on calcium transients and contraction in adult rat cardiomyocytes?
Population
Isolated cardiomyocytes obtained from adult rats
Comparison
N-acetylcysteine followed by TNF-alpha exposure vs Cardiomyocytes from control rats exposed to…
Design
Preclinical
Follow-up
20 minutes
Authors
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NAC may blunt TNF-alpha effects on rat cardiomyocyte function; hypothesis-generating for heart failure therapy with no human data yet.
Does N-acetylcysteine prevent the deleterious effects of TNF-alpha on calcium transients and contraction in adult rat cardiomyocytes?
Glutathione supplementation with N-acetylcysteine prevents the adverse contractile effects of TNF-alpha in rat cardiomyocytes, suggesting a potential therapeutic mechanism for heart failure.
Cailleret et al. (2004) studied this question.
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