Probable Cold Agglutinin Disease Presenting With Profound Anemia and Cardiopulmonary Decompensation in a 93-Year-Old Woman: A Case Report
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Key Points
This report aims to describe a case of probable cold agglutinin disease presenting with severe anemia and cardiopulmonary complications in a 93-year-old woman.
Case report of a 93-year-old woman with progressive anemia and symptoms of heart failure.
Evaluation included blood tests for hemolysis, cold-reactive antibodies, and serum immunofixation.
Transfusion and supportive care were provided, with careful monitoring for comorbid conditions.
Hemoglobin dropped from 9.7 g/dL to 5.1 g/dL due to severe normocytic anemia.
Successful transfusion support raised hemoglobin to 9.3 g/dL, improving symptoms of dyspnea and edema.
Patient remained stable at 12 weeks post-discharge, opting for conservative management without invasive testing.
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Implication
Case report finds probable cold agglutinin disease causing anemia in an elderly woman, highlighting diagnostic challenges.