Why the study?
Does I-123-MIBG SPECT identify myocardial sympathetic dysinnervation in patients with idiopathic long QT syndrome compared to healthy volunteers?
Population
12 members of four idiopathic long QT syndrome families and 8 healthy volunteers. Total n=20.
Comparison
I-123-MIBG single photon emission computed… vs Healthy volunteers
Design
Case-control
Authors
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Regional MIBG defects associate with QT prolongation and symptoms; leaves open clinical role of sympathetic imaging in long QT syndrome.
Does I-123-MIBG SPECT identify myocardial sympathetic dysinnervation in patients with idiopathic long QT syndrome compared to healthy volunteers?
Quantitative I-123-MIBG SPECT identifies congenital myocardial sympathetic dysinnervation as a structural defect in idiopathic long QT syndrome, demonstrating an autosomal-dominant inheritance pattern.
Göhl et al. (1991) studied this question.
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