Scintigraphic pattern of regional cardiac sympathetic innervation in patients with familial long QT syndrome using positron emission tomography.
Why the study?
Does scintigraphic evaluation with C-11 hydroxyephedrine PET show abnormal cardiac sympathetic innervation in patients with familial long QT syndrome compared to normal controls?
Population
9 patients with familial long QT syndrome and 14 asymptomatic volunteers
Comparison
Scintigraphic evaluation of cardiac sympathetic… vs 14 asymptomatic normal volunteers
Design
Case-control
Authors
Discussion
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Member takes
Implication
Challenges abnormal sympathetic nerve distribution in familial LQTS; leaves open functional mechanisms for further study.
Structured PICO
Does scintigraphic evaluation with C-11 hydroxyephedrine PET show abnormal cardiac sympathetic innervation in patients with familial long QT syndrome compared to normal controls?
P
Population
9 patients with familial long QT syndrome (3 men, 6 women; mean age 39 +/- 16 years) and 14 asymptomatic volunteers
I
Intervention
Scintigraphic evaluation of cardiac sympathetic innervation using C-11 hydroxyephedrine (HED) positron emission tomography (PET)
C
Comparator
14 asymptomatic normal volunteers
O
Outcome
HED retention index and HED uptake normalized to blood flowsurrogate
Patients with familial long QT syndrome have normal cardiac sympathetic innervation as assessed by HED PET, suggesting that any sympathetic imbalance is unlikely due to abnormal distribution of cardiac sympathetic nerves.
Cite This Study
Calkins et al. (1993) studied this question.