Why the study?
Does methadone cause QTc prolongation and torsades de pointes in patients treated for opioid addiction and pain?
Does methadone cause QTc prolongation and torsades de pointes in patients treated for opioid addiction and pain?
Methadone is associated with QT prolongation and torsades de pointes, necessitating awareness of its mechanisms, management, and potential genetic predispositions.
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Methadone QTc monitoring may be prudent in opioid therapy; review extends mechanistic insights while leaving genetic links open for validation.
Methadone is a drug that has found widespread utility in the management of opioid addiction and pain. Along with its popularity, methadone has also earned an infamous reputation for causing prolongation of the QT interval and an increased risk of torsades de pointes. In this article we will give a brief overview of the long QT syndromes, followed by an in-depth look at the current pathophysiologic mechanisms of methadone induced QT prolongation, a review of the existing literature and the current concepts regarding the prevention and management of methadone induced torsades de pointes. In addition, we explore the idea and implications of a genetic link between methadone induced prolongation of the QT interval and torsades de pointes.
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Mujtaba et al. (2013) studied this question.
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