Properties of the block of single Na+ channels in guinea‐pig ventricular myocytes by the local anaesthetic penticainide.
Population
Guinea-pig ventricular myocytes (cell-attached and inside-out patches)
Comparison
Penticainide applied in the pipette or bathing… vs Absence of penticainide
Design
Preclinical
Authors
Discussion
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Implication
Penticainide's Na+ channel effects remain preclinical; leaves open translation to human antiarrhythmic therapy.
Structured PICO
P
Population
Guinea-pig ventricular myocytes (cell-attached and inside-out patches)
I
Intervention
Penticainide (3 to 100 microM) applied in the pipette or bathing solution, with S-enantiomer of DPI 201-106 (5 microM) used to slow inactivation
C
Comparator
Absence of penticainide
O
Outcome
Single Na+ channel properties including open-state probability, mean open time, and closed timesurrogate
Penticainide blocks cardiac Na+ channels primarily by increasing the probability of sweeps with no activity and reducing mean open time.
Cite This Study
Carmeliet et al. (1989) studied this question.