April 1, 1991The Journal of PhysiologyOpen Access

Dual effect of the local anaesthetic penticainide on the Na+ current of guinea‐pig ventricular myocytes.

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Population

Guinea-pig ventricular myocytes

Design

Preclinical

Authors

RGRyan B. GruberJanssen (United States)JVJohan VereeckeKU Leuven ECEdward CarmelietElectrophysiology

Discussion

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Implication

Dual Na+ effects may unpredictably modulate excitability; leaves open net antiarrhythmic impact pending in vivo validation.

Structured PICO

Population

Guinea-pig ventricular myocytes

Intervention

Penticainide (3-60 microM) applied from the outside or cytoplasmic side

Outcome

Macroscopic and single-channel sodium current (INa)surrogate

Penticainide exerts a dual effect on sodium currents in guinea-pig ventricular myocytes, acting as an open channel blocker while also slowing macroscopic inactivation.

Cite This Study

Gruber et al. (1991) studied this question.

synapsesocial.com/papers/6a7993f1162060f9da88fbe7 https://doi.org/10.1113/jphysiol.1991.sp018498

View Full Paper

Ask AI

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Dual effect of the local anaesthetic penticainide on the Na+ current of guinea‐pig ventricular myocytes.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Dual effect of the local anaesthetic penticainide on the Na+ current of guinea‐pig ventricular myocytes.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider