Pinacidil interacts with ATP-sensitive K+ channels in guinea-pig ventricular myocytes through multiple sites or processes, including non-competitive antagonism of ATP and voltage-dependent block.
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Cautions against direct translation of pinacidil's KATP effects from guinea-pig myocytes; leaves open multi-site mechanisms in human ventricular channels.
Nakayama et al. (1990) studied this question.
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