Key result
Pinacidil acted as a nonselective K+ channel opener targeting both KATP and BKCa channels in human coronary artery vascular smooth muscle cells.
Pinacidil acts as a nonselective K+ channel opener targeting both KATP and BKCa channels in human coronary artery vascular smooth muscle cells.
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May influence coronary tone via nonselective mechanisms; leaves open therapeutic implications pending human studies.
Bychkov et al. (1997) studied this question. Pinacidil was evaluated on K+ currents. Pinacidil acted as a nonselective K+ channel opener targeting both KATP and BKCa channels in human coronary artery vascular smooth muscle cells.
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